Ketamine synthesis

[G.Patton]

can Ethyl benzoate be used instead of decalin?

joejoeYou can substitute decalin by cyclohexane, probably

 

[ELON-JAYZ]

You can substitute decalin by cyclohexane, probably

G.PattonSir,would like to ask in the last step 4,can Ethyl benzoate be used instead of decalin?

 

[ELON-JAYZ]

Can I ask you question. Why do you think chemists are writing exact amount of solvents and reagents in tutorials and articles?

G.PattonGot it, thank you sir

 

[Dopey]

1-bromocyclopentyl-(o-chlorophenyl)-ketone (CAS 6740-86-9) is commercially available. It is being sold in forms of white powder or brown oil. You mentioned “This bromoketone is unstable and must be used immediately”, if that’s the case then how do they sell it. The solution has a very dark color in most of the photos, is there any point in buying them?
And how about the powder? How can we use the powder?

 

[G.Patton]

1-bromocyclopentyl-(o-chlorophenyl)-ketone (CAS 6740-86-9) is commercially available. It is being sold in forms of white powder or brown oil. You mentioned “This bromoketone is unstable and must be used immediately”, if that’s the case then how do they sell it. The solution has a very dark color in most of the photos, is there any point in buying them?
And how about the powder? How can we use the powder?

DopeyHi, it can be stored in a fridge under inert atmosphere. But I'm not sure that it's commercially available.

 

[OrgUnikum]

Well, I searched the CAS number on google, and there were a lot of sellers on Echemi, Chemical book, etc. I even saw some sellers on here (bb), you can try.

But if it has to be stored in a fridge and under inert atmosphere then it’s probably not the best option.

DopeySame as with all highly reactive compounds which are sold: A stabilizer (or a mix of) is added, what else? That it has to be kept below 8°C and such is just for insurance reasons to shift responsibility as this way if something goes wrong the buyer has to prove that it was always below 8°C what is quite difficult to do. It is not like: "If not kept cold and inert it will explode" but it is "might go bad quickly after opened but thats your own fault, stop bitching we told ya".
Things you made yourself go bad fast as impurities catalyze deterioration and you often do not have the right preservatives.