One-pot Amphetamine Synthesis From P2NP With NaBH4/CuCl2 (1kg scale)

[Sasha89]

What do you use for external heating to keep the temperature on 80 °c for 30 mins?

 

[GDC]

What do you use for external heating to keep the temperature on 80 °c for 30 mins?

Sasha89Metal dog food feeding dish with water.

 

[T0lek511]

Can I replace CuCl2 with CuSO4. I read it on reddit and idk if is this possible but I think yes bc Cu(II) I am right?

 

[GDC]

Can I replace CuCl2 with CuSO4. I read it on reddit and idk if is this possible but I think yes bc Cu(II) I am right?

T0lek511CuSo4 is better then CuCl2

 

[GDC]

CuSo4 is better then CuCl2

GDC

https://chemistry.mdma.ch/hiveboard/palladium/pdf/Reduction%20of%20Organic%20Compounds%20with%20Sodium%20Borohydride-Copper(II)%20Sulfate%20System.pdf

 

[T0lek511]

@G.Patton
Hi. Can I use 15% sulphuric acid for making amp sulphate from freebase? In Czech Republic sulphuric acid is very restricted.

 

[GDC]

@G.Patton
Hi. Can I use 15% sulphuric acid for making amp sulphate from freebase? In Czech Republic sulphuric acid is very restricted.

T0lek511You have to concentrate it. By heat it up for hours I know the problems
Check it by density!

 

[G.Patton]

@G.Patton
Hi. Can I use 15% sulphuric acid for making amp sulphate from freebase? In Czech Republic sulphuric acid is very restricted.

T0lek511Hello, you can try. Take into account that your amphetamine sulphate will be dissolved in water of this solution.

 

[G.Patton]

So an extraction would be in order prior to precipitation to both get rid of the water and keep the amphetamine?

What do you recommend I do to get pure sulfuric or phosphoric acid? because I can't seem to find any sellers of acids, and domestic purchases aren't possible at the moment.

mithyl2You can carry out an extraction and dry its extract over MgSO4 or other drying agent. I don't know where are you from and any about your market, I can't answer you about acids. Buy it here. You can get sulphuric acid from accumulator electrolyte Production of concentrated sulfuric acid at home

 

[mithyl2]

You can carry out an extraction and dry its extract over MgSO4 or other drying agent. I don't know where are you from and any about your market, I can't answer you about acids. Buy it here. You can get sulphuric acid from accumulator electrolyte Production of concentrated sulfuric acid at home

G.PattonUK. The only thing that stops me from producing sulfuric acid myself is the purification part because it involves boiling the sulfuric acid it at high temps. and no sellers on here seem to sell pure acids.

 

[G.Patton]

UK. The only thing that stops me from producing sulfuric acid myself is the purification part because it involves boiling the sulfuric acid it at high temps. and no sellers on here seem to sell pure acids.

mithyl2You have to do it on open air only, it's quite dangerous. Use PPE for this.

 

[T0lek511]

Hello, yes, you can. Do not overheat the solution. In opposite case you'll loose the yield.

G.PattonHi @G.Patton. What gas is released in this reaction? I read on internet NaBH4 can release HCN gas? I think that isnt that case, but is there any option how can I unfortunatuly do that? I read NaBH4 is reacting with water by releasing H2 gas too. What gas is released by addition of P2NP into solution NaBH4 in IPA/Water? Sorry I have too many question but I dont want to kill myself by some stupid mistake.

 

[G.Patton]

Hi @G.Patton. What gas is released in this reaction? I read on internet NaBH4 can release HCN gas? I think that isnt that case, but is there any option how can I unfortunatuly do that? I read NaBH4 is reacting with water by releasing H2 gas too. What gas is released by addition of P2NP into solution NaBH4 in IPA/Water? Sorry I have too many question but I dont want to kill myself by some stupid mistake.

T0lek511Hello, H2.

I read on internet NaBH4 can release HCN gas?

It isn't possible, don't worry.

 

[T0lek511]

Hello, H2.

It isn't possible, don't worry.

G.PattonSo for safety is better use electric heater than propane-butane? How much hydrogen is made? Littlebit or much? The problem is I have only propane-butane heater, I will do only about 20g of P2NP. Is in this scale dangerous to use propane-butane heater?

 

[G.Patton]

So for safety is better use electric heater than propane-butane? How much hydrogen is made? Littlebit or much? The problem is I have only propane-butane heater, I will do only about 20g of P2NP. Is in this scale dangerous to use propane-butane heater?

T0lek511

>So for safety is better use electric heater than propane-butane?

Yes, of course

How much hydrogen is made? Littlebit or much?

You can calculate this according to the reaction equation and the molar constant of the gas (22.4 l/mol).

Is in this scale dangerous to use propane-butane heater?

I strongly do not recommend to use open flame because you'll get hydrogen and your lab can explode.

 

[GDC]

Hey,
can i use Tin(II)Chloride*2H2O instead of CuCL2*2H2O or CuSO4?

The addition of the catalyst ends with the complete black shadow inside the reaction mixture, right?

Will i have some different actions with ortho-phosphoric-acid? Warm place or something else? Any tips?

 

[GDC]

Hey,
can i use Tin(II)Chloride*2H2O instead of CuCL2*2H2O or CuSO4?

The addition of the catalyst ends with the complete black shadow inside the reaction mixture, right?

Will i have some different actions with ortho-phosphoric-acid? Warm place or something else? Any tips?

GDC#Tin2Chloride -> I think not because isn't a transfer metal ---but just asking xD

 

[malignoalfa]

Can I use a digital ph meter in this synthesis? Could you give an example of one that would work?

 

[malignoalfa]

A doubt. When adding the NaOH solution, if the PH reaches 11 before adding the entire solution, should I stop adding it? And if you add more of the NaOH solution, making it too basic, would there be a problem? Thank you for your attention.

 

[malignoalfa]

In this synthesis, can I use 95% ethanol instead of IPA? I believe any pure alcohol would work, but it doesn't hurt to ask.
What would be the second and third best option in relation to acetone? I have trouble getting acetone.

 

[malignoalfa]

If I'm not interested in a-oil, can I skip evaporating the IPA for 30min at 80c? I believe so, because I go straight to the sulfate.