Cocaine Synthesis from Tropinone

[thankyou888]

I will definitely try it and share you video tutorials

Bcz this is seriously unexplored thing.
If this is possible than production cost of cocaine would be near about$500-$700

I also interested for it.

 

[Tetrachlor]

I will definitely try it and share you video tutorials

Bcz this is seriously unexplored thing.
If this is possible than production cost of cocaine would be near about$500-$700

I also interested for it.

thankyou888When?

 

[chemistrydude]

This synthesis of Cocain was noted from Psychedelic Chemistry by Michael Valentine Smith (Page140-144).

<b> Preperation of 2-carbomethoxytropinone from Tropinone </b>

(1) Mixture of 1.35 g Sodium methoxide, 3.48 g Tropinone, 4 ml Dimethylcarbonate and 10 ml Toluene.
(2) Reflux ½ hour, cool to 0° and add 15 ml water containing 2.5 g NH Cl.
(3) Extract with 4X50 ml CHCI2, dry and evaporate in vacuum and dissolve the oil in 100 ml ether.
(4) Wash two times with a mixture of 6 ml saturated aqueous Potassium carbonate and 3 ml 3N Potassium Hydroxide(dry and evaporate in vacuum the ether to recover unreacted tropinone).
(5) Take up the oil which separates in saturated aqueous NH4Cl and extract it with CHCI2.
(6) Dry and evaporate in vacuum to get an oil which is dissolved in hot acetone.
(7) Cool, add a little water and rub to start precipitation of 1.5 g 2-carbomethoxytropinone.

<b> Preperation of Methylecgonine from 2-carbomethoxytropinone </b>

(1) Reflux 2-carbomethoxytropinone and NaBH4 in methanol for six hours to yield 50% Methylecgonine.

<b> Preperation of Cocaine from Methylecgonine </b>

(1) Stir and heat mixture of 4 g Methylecgonine, 36 ml Benzene, 1.6 g Sodium carbonate and 7 ml Benzoyl-Cl for ten hour at 96-100°C.
(2) Evaporate in vacuum, cool to 0° and add 40 ml ice water.
(3) Acidify with HCI to pH 5 and extract with 3X20 ml ether.
(4) Neutralize the aqueous solution with 20% NH4OH to separate an oil from which cocaine precipitates on standing.

Isn't this synthesis to produce Synthetic cocaine looks easy.? All Precursor are easily available in market and also cheap.

Please give some light on topic /u/HEISENBERG , /u/G.Patton , /u/William Dampier .

thankyou888Most of darkweb RC forums has synthesis of cocaine, it's right formula, but the yield quite will be low, so i recommend doing it from plant, im not expert at cocaine but coca leafs is better

 

[thankyou888]

Most of darkweb RC forums has synthesis of cocaine, it's right formula, but the yield quite will be low, so i recommend doing it from plant, im not expert at cocaine but coca leafs is better

chemistrydudeIf we get yield of even 50% than also considering price of cocaine and price of reagents it is very cheap to manufacture.

 

[Tetrachlor]

We got very high yield than that. As a user we tested it. It is highly potent. We have sended sample to energy control. When we get results we will update it.

thankyou888Want to do this, can you helpe please?

I can get 2-CMT

 

[Tetrachlor]

We got very high yield than that. As a user we tested it. It is highly potent. We have sended sample to energy control. When we get results we will update it.

thankyou888Please Tell me results.
Im very interested in this.

 

[Ecko6ap]

i know where to buy methylecgonine

 

[Tetrachlor]

i know where to buy methylecgonine

Ecko6apWhere? Price?

 

[Ecko6ap]

Where? Price?

TetrachlorGo to pm

 

[OmID]

Do you mean Dichloromethane(Ch2cl2) by Chcl2 ?

CHCI2

thankyou888

 

[Frit Buchner]

Do you mean Dichloromethane(Ch2cl2) by Chcl2 ?

OmIDMethylene chloride aka chlorofirm

 

[Tetrachlor]

Have some questions.

The Reduktion of 2cmt with NaBH result in 50% eme. What ist the Rest?

And How to separate eme from this mixture for Further use?

 

[Frit Buchner]

Have some questions.

The Reduktion of 2cmt with NaBH result in 50% eme. What ist the Rest?

And How to separate eme from this mixture for Further use?

TetrachlorThe difference between them is a carbinol in 2-cmt is replaced by a hydroxy. 2-cmt gains 1 hydrogen . The other likely compounds produced are sodium metaborohydrate and hydrogen gas (H2)

 

[The-Hive]

this what yous lookinggg for........

In an oven-dried 100-ml round bottom flask was added 1.00g (4.25 mmol) of (+)-ecgonine methyl ester HCl with 7 ml of dry pyridine and stirred in an ice bath. The reaction was protected from moisture with argon. Dropwise over 5 min was added a solution of 0.8 ml (6.85 mmol) of benzoyl chloride in 5 ml of pyridine. After addition was complete the ice bath was removed and the reaction was stirred 24 h under argon. Dry acetone (200 ml) was added and the slurry was filtered by suction filtration. The crude (+)-cocaine hydrochloride was washed with an additional 100 ml of dry acetone. The product was dried yielding 1.28 g (89%). The hydrochloride was dissolved into 20 ml of water, made pH 8 with 5% ammonium hydroxide, and extracted 4 times with 50 ml of methylene chloride. The solvent was dried over sodium sulfate and evaporated in vacuo. The free base was recrystallized from diethyl ether and petroleum ether yielding 1.01 g (78%) of pure (+)-cocaine base, [α]D24 +35.8° (c=1, 50% aqueous EtOH), mp 96.0-97.5°C. The literature48 lists the (-)-enantiomer at [α]D24 -35° (c=1, 50% aqueous EtOH), mp 98°C.

Racemic and (-)-cocaine can be synthesized using the same benzoylation procedure and clean-up using (+)-EME and (-)-EME respectively.

 

[Frit Buchner]

The difference between them is a carbinol in 2-cmt is replaced by a hydroxy. 2-cmt gains 1 hydrogen . The other likely compounds produced are sodium metaborohydrate and hydrogen gas (H2)

 

[Frit Buchner]

The major metabolites of cocaine detected in urine are
Benzoyl ecgonine
Ecgonine methylester
1 simply needs an esterification (a reduction and methylation)
2 simply needs a benzoylation described above.

I'm not saying recycle your piss, but. You could

 

[Frit Buchner]

There are 4 chiral carbons for 8 possible isomers, Whatever you're expecting for yield, devide it by 8

 

[HerrHaber]

I am somewhat afraid to help.

 

[The Alchemist]

I'm very interested to see a video on this. It sounds like OP did the synthesis at least once. Will you post the results from EC or tell us the proportion of isomers? What was the cost to produce? If the isomers are similar to cocaine, but not cocaine, which yeild are you reporting? If your product has cocaine isomers in it, it's not really cocaine, it's a blend.

We could extract it from plant matter, but we're not all in South America. We could make similar drugs, but if we're making similar drugs then there are already better drugs, imo.

Can someone answer if this route is viable on a small scale if one didn't plan to profit from it? How much would it take to produce, say 30gs?

 

[The-Hive]

Best I can do

 

[Germanium]

Is it possible to synthesize Methylecgonidine from Methylecgonine?

 

[Frit Buchner]

Is it possible to synthesize Methylecgonidine from

GermaniumMy bad, I read that backwards.it involves a reduction and a hydroxylation, but I don't know the pathway

Methylecgonidine - Wikipedia

en.m.wikipedia.org

 

[Germanium]

My bad, I read that backwards.it involves a reduction and a hydroxylation, but I don't know the pathway

Methylecgonidine - Wikipedia

en.m.wikipedia.org

Frit BuchnerI found it too difficult for me haha
Cocaine analogues such as RTI-31 were interesting and I wanted to try to synthesize them.
Anyway, thank you so much!

 

[Frit Buchner]

The CHINESE will sell you 2-cmt, which is only a couple Reactions away. I got a price quote from them but I couldn't afford it based on my fear that I couldn't pull it off. They quoted me $150 for a 10g sample. So you are probably looking at...idk, $10,000 kg?
I know it works because about 1 out of 200 samples tested by drugs-data, where you mail it in and pay $100, is synthetic cocaine.

2-Carbomethoxytropinone - Wikipedia

en.m.wikipedia.org

 

[Germanium]

The CHINESE will sell you 2-cmt, which is only a couple Reactions away. I got a price quote from them but I couldn't afford it based on my fear that I couldn't pull it off. They quoted me $150 for a 10g sample. So you are probably looking at...idk, $10,000 kg?
I know it works because about 1 out of 200 samples tested by drugs-data, where you mail it in and pay $100, is synthetic cocaine.

2-Carbomethoxytropinone - Wikipedia

en.m.wikipedia.org

Frit BuchnerIf I want to synthesize from 2 cmt, what is the procedure?
Any examples would be helpful...

 

[Frit Buchner]

If I want to synthesize from 2 cmt, what is the procedure?
Any examples would be helpful...

GermaniumI wrote about it, either above or in another thread about this topic. An alkylation reaction (methylation) and a Fischer esterfication are the 2 reactions. You can find examples in pretty much every cocaine synthesis scheme. I wouldn't suggest one over another based on I haven't done it.

 

[Germanium]

I wrote about it, either above or in another thread about this topic. An alkylation reaction (methylation) and a Fischer esterfication are the 2 reactions. You can find examples in pretty much every cocaine synthesis scheme. I wouldn't suggest one over another based on I haven't done it.

Frit BuchnerOkay. Thanks!
I will search more and read past posts.

 

[Germanium]

Buy Methylecgonidine - 43021-26-7 | BenchChem Benchchem offers qualified products for CAS No. 43021-26-7 (Methylecgonidine), please inquire us for more detail. www.benchchem.com This site describes the synthesis passway but I personally doubt this will work. Design of the Synthesis Pathway The synthesis pathway of Methylecgonidine involves the conversion of ecgonine methyl ester to Methylecgonidine through a series of chemical reactions. Starting Materials Ecgonine methyl ester, Methyl iodide, Sodium hydroxide, Hydrochloric acid, Sodium bicarbonate, Ethanol Reaction Step 1: Ecgonine methyl ester is reacted with methyl iodide in the presence of sodium hydroxide to form N-methyl ecgonine methyl ester. Step 2: N-methyl ecgonine methyl ester is then hydrolyzed with hydrochloric acid to form N-methyl ecgonine. Step 3: N-methyl ecgonine is then reacted with sodium bicarbonate and ethanol to form Methylecgonidine.