Question: What Is The Full Process With Measurements For The Synthesis of Acryl-Fentanyl?

[Cody Ashmore]

I found this question in the opioids section someone please answer it. We wanna know. It supposedly lasts longer than fentanyl

 

[Cody Ashmore]

Here is a sample can anyone simplify this and add a materials/ingredients list, as well as the procedure/measurements for synthesis?


The two published synthetic methods of acryloylfentanyl
describe the acylation of the common precursor
4-ANPP (25,26) with acryloyl chloride (27) (Zhu et al., 1981;
Maryanoff et al., 1982) or 3-chloropropionyl chloride (28)
Acylation of 4-ANPP with acryloyl chloride in the
presence of a base, such as sodium carbonate, in an
inert solvent affords directly acryloylfentanyl . In the similar synthesis of the acroyl analogue
of the analgesic 2,5-dimethylfentanyl (phenaridine, also
spelled as fenaridin) a 1.5 molar equivalent triethylamine
was used (Vartanyan et al., 1989). The use of an
additional base is, however, not necessary since the
basic piperidine moiety present in the substance may
serve as an acid scavenger.
Alternatively, acylation with 3-chloropropionyl chloride in
the presence of an excess of a base, such as
triethylamine, results in the simultaneous elimination of
hydrochloride to provide the desired acryloyl product.

 

[Cody Ashmore]

They say it's like fent though it lasts all day, this might result is less dosing times which require specific measurements that may result in life and death if done improperly, so possibly less overdoses. Harm Reduction right?

 

[ymaaah]

They say it's like fent though it lasts all day, this might result is less dosing times which require specific measurements that may result in life and death if done improperly, so possibly less overdoses. Harm Reduction right?

Cody Ashmoreyeah but fent is fent... still dangerous and hard to dose.. take care my man