Amphetamine synthesis from P2NP via Al/Hg (video)

[HEISENBERG]

thanks for the video it was quite enlightening to bad my crappy network speed made it watching this a nightmare

KaiVideo instructions are very convenient for those who are just taking their first steps. For more experienced chemists, simple instructions are sufficient. You can download this video.

 

[spongebomb]

Video instructions are very convenient for those who are just taking their first steps. For more experienced chemists, simple instructions are sufficient. You can download this video.

HEISENBERGyears ago, videos like this would have helped me so much not to have to search for and combine all my knowledge as a layman somewhere among half-truths. Plus the often incorrect translation ... not everything was better back then

 

[HIGGS BOSSON]

Why on erowid People who do IT reaction uses diluted glacial acetic acid ~ about 70-75% for reduction?
And second thing they are uses more acid to reduce nitropropene for 1g p2np they use 10 ml GAA and dilute IT with water.

In synthesis from this topic, for 1g p2np they use 5ml GAA.

Its 50% different for reagent who give Hydrogen in reduction.

What reduction will be better? With water (from erowid) or without water (this topic)?

Reduction of Nitroalkenes with Aluminium Amalgam - [www.rhodium.ws]

Text from this link:
#4. Reduction of unsubstituted P2NP by HyperLab Bee #2.


Into a 3-L FBF there was placed 100 mls water, 250mls GAA and a solution of 1g mercury in 2-3 mls conc. HNO3.
52 g (2 packs 10 meters each) of Al foil were folded into 7-8 layers, cut in pieces 3x3 cm and loaded into the flask.
The flask was heated to 40 °C. When the start of amalgamation was clearly visible in several minutes, heating was discontinued and into the reaction there was added a suspension of 30 g non-recrystallized phenyl-2-nitropropene in a mixture of 50 mls GAA and 100mls IPA (nitropropene was obtained a la Barium’s MeAm condensation - an important notion since this method gives the product of superior purity).

pdwshopnlYou can use diluted acetic acid. Excess acid does not interfere with reduce, but it will have to be extinguished with the appropriate amount of alkali, which will lead to an increased consumption of reagents and time, since more heat will be released when the acid interacts with the alkali. In the described technique, they simultaneously carry out amalgamation with a mercury salt and a reduction reaction. In my technique, the foil is first treated with an aqueous solution of mercury salt, which is then drained, which makes the product cleaner.

 

[TIMBER12]

You can use diluted acetic acid. Excess acid does not interfere with reduce, but it will have to be extinguished with the appropriate amount of alkali, which will lead to an increased consumption of reagents and time, since more heat will be released when the acid interacts with the alkali. In the described technique, they simultaneously carry out amalgamation with a mercury salt and a reduction reaction. In my technique, the foil is first treated with an aqueous solution of mercury salt, which is then drained, which makes the product cleaner.

HIGGS BOSSONWill I be okay if I used %94 acetic acid?

 

[blacky2340]

Ahh, I see. Thanks!

 

[ENZO]

It is possible to precipitate with 36% hcl (if possible I imagine that it will precipitate in the form of hydrochloride). I can't easily get sulfuric

 

[ju3]

Can we change Isopropyl Alcohol whit Methanol or Ethanol?

 

[flyhigh2]

can you beleive using 10g p2np my yeild is on;y 1g of salt , im breaking my head where i lost, iam sure i lot 1g to filtering paper, how to avoid it

flyhigh2Reflux the reaction mixture for 2 hours after its done reacting with hg

 

[blacky2340]

can you beleive using 10g p2np my yeild is on;y 1g of salt , im breaking my head where i lost, iam sure i lot 1g to filtering paper, how to avoid it

flyhigh2Reflux the reaction mixture for 2 hours after its done reacting with hg

 

[41Dxflatline]

Isopropyl can be salted out to its own layer from the basified reaction mixture. Otherwise use DCM, petroleum ether or naptha.
If you can't get concentrated H2SO4 use phosphoric acid. You can use HCl but thats really a last resort.

 

[voiden]

I was able to successfully make my own amphetamine for the first time ever.
Damn i love the smell and taste of the pure substance ! .

Shout out to my "ex" dealer that he pushed me into this direction.
I was really pissed and fed up of his inconsistent quality speed.

Now i have the good stuff and will never be dependent on greedy dealers.

Here some pics

 

[Toribius]

Steam distillation of A-oil can be done like in the p2p steam distillation video?
This steam distillation after vacuum distillation of solvents, right?

 

[HIGGS BOSSON]

Steam distillation of A-oil can be done like in the p2p steam distillation video?
This steam distillation after vacuum distillation of solvents, right?

ToribiusSteam distillation of A-oil can be done like in the p2p steam distillation video?
Yes

 

[drjesus1]

i heard that you can use acetic acid instead of sulfuric, is this true?

 

[blacky2340]

i heard that you can use acetic acid instead of sulfuric, is this true?

drjesus1Not for acidification. Try looking for a drain cleaner with it, or concentrating battery acid, or just buy it online

 

[drjesus1]

Is not acidification and and ph adjustment the same thing? Thats what i meant it could be replaced by any acid for ph regulation.

 

[TheCook]

Is not acidification and and ph adjustment the same thing? Thats what i meant it could be replaced by any acid for ph regulation.

drjesus1Acidification and pH adjustment are not the same thing, because pH adjustment can also mean basification.

As different salts have different physical, chemical and pharmaceutical properties, it is better to choose a suitable salt.
Amphetamine acetate has no practical significance (except, for example, for reduction via Al/Hg).

But you are welcome to try it and report back.

 

[Cranston]

Acidification and pH adjustment are not the same thing, because pH adjustment can also mean basification.

As different salts have different physical, chemical and pharmaceutical properties, it is better to choose a suitable salt.
Amphetamine acetate has no practical significance (except, for example, for reduction via Al/Hg).

But you are welcome to try it and report back.

TheCookConfirmed. Real chemist landed here. @Gordon Ramsay check him

 

[yuiopjkl]

Acidification and pH adjustment are not the same thing, because pH adjustment can also mean basification.

As different salts have different physical, chemical and pharmaceutical properties, it is better to choose a suitable salt.
Amphetamine acetate has no practical significance (except, for example, for reduction via Al/Hg).

But you are welcome to try it and report back.

TheCookI searched for a while about the difference between amphetamine salts in terms of pharmaceutical properties, but I did not find any useful information.

If you have any information or references, please send them to me
Thanks in advance

 

[chef learner]

I want to ask about it!
Regarding the feasibility and correctness of this approach.

I have tried the process in the video and here is how I did it. I don’t know why the final output is not the same as the quantity in the video.

First use IPA 100ml+H2O 50ml+P2NP 10g. After heating and dissolving, let it cool until crystals appear.

Prepare 12g aluminum flakes + 2g HgCL2 (because I can’t get the mercury nitrate and can only use mercury chloride to make aluminum amalgam), put it in a flask and react for about 30 to 40 minutes, and connect the condenser tube

The cooled and crystallized P2NP is easily added to 50ml of glacial acetic acid and heated to dissolve.

Remove the gray dirty water from the aluminum flakes and wash them twice with pure water

Then add the P2NP solution into the aluminum flask (at this time there will be a large amount of reaction and the temperature will rise rapidly. Use a cold bath to cool down the temperature and shake the flask regularly during the process). The reaction process is about 30~40 minutes.

Take out the solution from the flask and there will be a gray liquid and a small amount of aluminum flakes

Previously prepared 50g NaOH+70ml H2O solution, add the sodium hydroxide solution to the gray liquid to bring the liquid pH to 11

Reaction takes about 30 minutes
A yellow liquid will appear. Take out this liquid (the gray substance is not extracted) and put it in the refrigerator for 1 hour.

After cooling, add this light yellow liquid to IPA 1:1 and stir
Add concentrated sulfuric acid and drop in a small amount. At this time, white objects will appear, making the liquid appear milky white with sediment.
Bring pH to 5.5

After refrigerating the liquid for 24 hours, filter and dry the white product (is the product at this time correct? And the final P2P required)

For this part, my final product is only about 1~2g, which doesn’t seem right.
I've tried hard to find the answer but I still haven't gotten the right idea. Could you please give me some correct guidance?

What factors affect the yield (the final product in the video seems to be far more than the number of my experiments)

I welcome people who have succeeded with this method and the yield is about 70~80% to guide me.
please


Aluminum foil and aluminum flakes are made into aluminum amalgam and then sodium hydroxide solution is added. Why is the aluminum flake a slightly yellowish liquid, but the aluminum foil is a white liquid?
The aluminum foil I use is household aluminum foil used in the kitchen. Is this okay to use?

 

[TheCook]

I want to ask about it!
Regarding the feasibility and correctness of this approach.

I have tried the process in the video and here is how I did it. I don’t know why the final output is not the same as the quantity in the video.

First use IPA 100ml+H2O 50ml+P2NP 10g. After heating and dissolving, let it cool until crystals appear.

Prepare 12g aluminum flakes + 2g HgCL2 (because I can’t get the mercury nitrate and can only use mercury chloride to make aluminum amalgam), put it in a flask and react for about 30 to 40 minutes, and connect the condenser tube

The cooled and crystallized P2NP is easily added to 50ml of glacial acetic acid and heated to dissolve.

Remove the gray dirty water from the aluminum flakes and wash them twice with pure water

Then add the P2NP solution into the aluminum flask (at this time there will be a large amount of reaction and the temperature will rise rapidly. Use a cold bath to cool down the temperature and shake the flask regularly during the process). The reaction process is about 30~40 minutes.

Take out the solution from the flask and there will be a gray liquid and a small amount of aluminum flakes

Previously prepared 50g NaOH+70ml H2O solution, add the sodium hydroxide solution to the gray liquid to bring the liquid pH to 11

Reaction takes about 30 minutes
A yellow liquid will appear. Take out this liquid (the gray substance is not extracted) and put it in the refrigerator for 1 hour.

After cooling, add this light yellow liquid to IPA 1:1 and stir
Add concentrated sulfuric acid and drop in a small amount. At this time, white objects will appear, making the liquid appear milky white with sediment.
Bring pH to 5.5

After refrigerating the liquid for 24 hours, filter and dry the white product (is the product at this time correct? And the final P2P required)

For this part, my final product is only about 1~2g, which doesn’t seem right.
I've tried hard to find the answer but I still haven't gotten the right idea. Could you please give me some correct guidance?

What factors affect the yield (the final product in the video seems to be far more than the number of my experiments)

I welcome people who have succeeded with this method and the yield is about 70~80% to guide me.
please


Aluminum foil and aluminum flakes are made into aluminum amalgam and then sodium hydroxide solution is added. Why is the aluminum flake a slightly yellowish liquid, but the aluminum foil is a white liquid?
The aluminum foil I use is household aluminum foil used in the kitchen. Is this okay to use?

akabing09876

Take out this liquid (the gray substance is not extracted) and put it in the refrigerator for 1 hour.

How did you remove the top layer? If you pour it off or picked it up with a syringe, you will lose a lot of product.
It is better to use a separating funnel (at least 500ml, preferably 1000ml). It should be large enough to hold the entire reaction mixture and still have 1/4 space at the top. Then add 25ml diethyl ether (or better MTBE, as this does not form peroxides) and seal with a stopper. Once you have made sure that the separatory funnel is absolutely tight, turn it upside down until there is no more liquid above the tap and open it briefly to release the pressure. Close it again, shake it again briefly and open it again. Keep doing this until no more pressure escapes.
Then shake vigorously for 3 minutes, clamp it in a stand and wait until the phases have separated. Drain the bottom phase with the aluminium hydroxide (don't forget to remove the stopper from the separating funnel first!) If you tilt the separating funnel slightly while draining, no aluminium will stick to the glass. Then tip the upper phase (from the top of the separating funnel!) into a beaker. Repeat the process 3 times by pouring the aluminium slurry back into the separating funnel with 25 ml of fresh ether.
Finally, combine the ether phases and wash them in the separating funnel 3 times with 0.01N NaOH.
After that, dry the ether over anhydrous magnesium sulphate over night and proceed with precipitation of the desired amphetamine salt.

 

[bobbrown1488]

is this the thick foil ? i was reading on here that the foil should be 3 or 4 layers thick , would you have any advice here ?
thank you

 

[WillD]

is this the thick foil ? i was reading on here that the foil should be 3 or 4 layers thick , would you have any advice here ?
thank you

bobbrown1488Do not take thick foil, it will react for a long time. Moreover, do not fold it in layers.